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Dr. IHW Nicholas

Senior Lecturer

Medicine

Email : iroshahvn@med.sab.ac.lk

    Qualifications

  • BSc. Chemistry (Special) University of Sri Jayewardenepura

    PhD , University of Peradeniya

    Research Interests

  • Nutrition, Nano chemistry, nano based drug delivery, Natural products chemistry, Nutraceuticals

    Improving the bioavailability of bioactive components using nano polymeric delivery systems.

    Nanoencapsulation of natural medicine and formulation of nutraceuticals.

     

    Recent Publications

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    1. Wickramaratne, M.N., Gunatilake, L.P., Anuradha, N.G.D., Godavillathanna, A.N., Perera, M.G.N. and Nicholas, I. (2015). Antioxidant activity and antibacterial activity of Walidda antidysenterica. Journal of Pharmacognosy and Phytochemistry 4(2), 121-126.

     

    External supervisor of Ms. L.P. Gunatilake- University of Sabaragamuwa.

     

    1. Fernando, T.M.M., de Silva, E.D., Wijayarathna, C.D., Senadeera, S.P.D., de Silva, P.G.S.M. and Nicholas, I.H.V. (2014). Investigation of Antimicrobial properties of endophytic fungi isolated from Neoclitsea cassia ("dawul kurundu" or "wild cinnamon"). Proceedings of MRI Research Day Scientific Sessions, Medical Research Institute, Colombo, 22.

     

    External supervisor of Ms. T.M.M. Fernando- University of Colombo.

     

    1. Wijendra, W.A.S., Nicholas, I.H.V. and Rangama, B.N.L.D. (2012). Antibacterial and antifungal activity in Flueggea leucopyrus (Willd). Proceedings of MRI Research Day Scientific Sessions, Medical Research Institute, Colombo, 22.

     

    1. Nicholas, I.H.V., Karunaratne, V., Amarathunge, G.A.J. and Karunaratne, D.N. (2016). Preparation and characterization of linamarin encapsulated chitosan nanoparticles, Proceedings of Research Congress (RESCON), Post Graduate Institute of Science, University of Peradeniya, 68.

     

    1. Nicholas, I.H.V., Karunaratne, V. Amarathunge, G. A. J. and Karunaratne, D.N. (2016). In-vitro release study of linamarin encapsulated chitosan nanoparticles. Proceedings of Peradeniya University International Research Sessions (iPURSE), University of Peradeniya, 255.

     

    1. Nicholas, I.H.V., Karunaratne, V., Amarathunge, G.A.J., Karunaratne, D.N. and Samarakoon, S.R. (2017). In vitro cytotoxicity of linamarin encapsulated chitosan nanoparticles against human breast cancer cells. Proceedings of the International Symposium on Traditional and Complementary Medicine (TradMed), Colombo.

     

    1. Nicholas, I.H.V., Karunaratne, V., Amarathunge, G.A.J. and Karunaratne, D.N. (2017). Linamarin encapsulated chitosan nanoparticles: preparation, characterization and in vitro release studies. Proceedings of the International Symposium on Traditional and Complementary Medicine (TradMed), Colombo, Sri Lanka.

     

    1. I. H. V. Nicholas, Weranga Rajapakse, G. A. J. Amaratunga, D. N. Karunaratne, and V. Karunaratne, (2018). A nano delivery system for combination therapy of iron and folic acid .Asian Symposium on Medicinal Plants, Spices and Other Natural Products XVI, Colombo, Sri Lanka.

     

    1. I. H. V. Nicholas, V. Karunaratne, G. A. J. Amaratunga, D. N. Karunaratne, S. R. Samarakoon, R. M. C. J. Bandara, S. R. K. M. Hewage and K. Perera (2018). Development and evaluation of linamarin loaded alginate nanoparticles.Asian Symposium on Medicinal Plants, Spices and Other Natural Products XVI, Colombo, Sri Lanka.

     

    1. K. Perera, D. M. R. K. Dissanayake, I. H. V. Nicholas, S. K. Rodrigo, D. N. Karunaratne, V. Karunaratne1, and G. A. J. Amaratunga (2018). Delivery of linamarin as an anticancer agent using folic acid-functionalized chitosan-alginate nanoparticles. The Asian Symposium on Medicinal Plants, Spices and Other Natural Products XVI, Colombo, Sri Lanka.

     

    1. D. Nedra Karunaratne, Geethi K. Pamunuwa, Irosha H. V. Nicholas, and Isuru R. Ariyarathna.(2019). Strategies for enhancement of bioavailability and bioactivity of curcumin. Science of Spices and Culinary Herbs - Latest Laboratory, Pre-clinical, and Clinical Studies: Volume 1, pp.104-147.

     

    1. I. H. V. Nicholas, V. Karunaratne, G. A. J. Amaratunga, D. N. Karunaratne, S. R. Samarakoon, and R. M. C. J. Bandara. (2020). Chitosan-Alginate Nanoparticles as a Novel Delivery System for Linamarin. Proceedings of 10th Annual Research Session- 2020, Sabaragamuwa University of Sri Lanka, 16.

     

    1. W. Rajapaksha, I. H. V. Nicholas, T. Thoradeniya, D. N. Karunaratne and V. Karunaratnea, (2024). Novel alginate nanoparticles for the simultaneous delivery of iron and folate: a potential nano-drug delivery system for anaemic patients. RSC Pharmaceutics, DOI: 10.1039/d3pm00068k